I am a
Home I AM A Search Login

Papers of the Week


Papers: 12 Oct 2024 - 18 Oct 2024


2024


Front Vet Sci


39376917


11

Subcutaneous and orally self-administered high-dose carprofen shows favorable pharmacokinetic and tolerability profiles in male and female C57BL/6J mice.

Authors

Glasenapp A, Bankstahl JP, Bähre H, Glage S, Bankstahl M

Abstract

Surgical interventions in mice require appropriate pain relief to ensure animal welfare and to avoid influence of pain on research findings. Carprofen is a non-steroidal anti-inflammatory drug commonly used as an analgesic for interventions inducing mild to moderate pain in laboratory rodents. Despite its frequent use, species-specific data on pharmacokinetics (PK), side effects, and potential impact on behavioral pain indicators are limited.