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Papers of the Week

Papers: 25 May 2024 - 31 May 2024

2024 May 24

Br J Pharmacol


Subcutaneous administration of a novel TRPM8 antagonist reverses cold hypersensitivity while attenuating the drop in core body temperature.


Gold MS, Pineda-Farias JB, Close D, Patel S, Johnston PA, Stocker SD, Journigan VB


We extend the characterization of the TRPM8 antagonist VBJ103 with tests of selectivity, specificity and distribution, therapeutic efficacy of systemic administration against oxaliplatin-induced cold hyperalgesia and the impact of systemic administration on core body temperature (CBT).