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Papers of the Week

Papers: 10 Jun 2023 - 16 Jun 2023

Basic Science

Animal Studies, Neurobiology, Pharmacology/Drug Development

CRPS, Psychological/Comorbidities

2023 Jun 14

Mol Pain


Sub-Anaesthetic Dose of Propofol Attenuates Mechanical Allodynia in Chronic Post-Ischaemic Pain via Regulation of PTEN/PI3K/IL-6 Signalling.


Leung SYD, Meng F, Liu J, Liu AJ, Ng HLL, Cheung CW, Wong SCS


Propofol is an intravenous anaesthetic drug that has been shown to reduce inflammatory pain. Complex regional pain syndrome (CRPS) type I is a pain condition characterized by autonomic, motor and sensory disturbance. The chronic post-ischaemic pain (CPIP) model is a well-established model to recapture CRPS-I syndromes pre-clinically by non-invasive ischaemic-reperfusion (IR) injury. In this study, we investigated the analgesic effects of propofol and underlying mechanisms in mitigating CRPS pain using the CPIP model.