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Papers of the Week


Papers: 1 Apr 2023 - 7 Apr 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Neurobiology, Pharmacology/Drug Development


2023 Apr 03


Protein Pept Lett


37016524

Study on the analgesic activity of peptide from Conus achates.

Authors

Liu X, Wang F, Yu H, Liu C, Xia J, Ma Y, Jiang H

Abstract

As a peptide originally discovered from Conus achates by mass spectrometry and cDNA sequencing, Ac6.4 contains 25 amino acid residues and three disulfide bridges. Our previous study found that this peptide possesses 80% similarity to MVIIA by BLAST and that MVIIA is a potent and selective blocker of N-type voltage-sensitive calcium channels in neurons.