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Papers of the Week


Papers: 30 Mar 2024 - 5 April 2024


2024 Mar 28


J Headache Pain


38549121


25


1

Structural equation modeling for identifying the drivers of health-related quality of life improvement experienced by patients with migraine receiving eptinezumab.

Authors

Jönsson L, Awad SF, Regnier SA, Talon B, Kymes S, Lee XY, Goadsby PJ

Abstract

As new migraine therapies emerge, it is crucial for measures to capture the complexities of health-related quality of life (HRQoL) improvement beyond improvements in monthly migraine day (MMD) reduction. Investigations into the correlations between MMD reduction, symptom management, and HRQoL are lacking, particularly those that focus on improvements in canonical symptoms and improvement in patient-identified most-bothersome symptoms (PI-MBS), in patients treated with eptinezumab. This exploratory analysis identified efficacy measures mediating the effect of eptinezumab on HRQoL improvements in patients with migraine.