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Papers of the Week


Papers: 29 Apr 2023 - 5 May 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Neurobiology

PAIN TYPE:
Itch


2023 Apr 30


J Neuroinflammation


37122031


20


1

STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice.

Authors

Li N, Wang C, Zhao Y, Wang Y, Gao T, Yu Y, Wang G, Zhang L

Abstract

Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an innate immune modulator, is strongly implicated in pain pathogenesis via neuron-immune modulation. Given that pain and itch share some common neurocircuits, we evaluate the therapeutic potential of STING agonists in opioid-induced itch and chronic itch.