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Papers: 29 Apr 2023 - 5 May 2023
RESEARCH TYPE:
Basic Science
Animal Studies, Molecular/Cellular, Neurobiology
PAIN TYPE:
Itch
2023 Apr 30
J Neuroinflammation
20
1
Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an innate immune modulator, is strongly implicated in pain pathogenesis via neuron-immune modulation. Given that pain and itch share some common neurocircuits, we evaluate the therapeutic potential of STING agonists in opioid-induced itch and chronic itch.