I am a
Home I AM A Search Login

Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025 Jan 22


Br J Anaesth


39848871

Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain.

Authors

Wang C, Di A, Wu Y, Liu M, Wei M, Liang Z, Liu F, Fan H, Dong B, Li C, Xu T, Xin W, Feng X

Abstract

Chronic neuropathic pain generally has a poor response to treatment with conventional drugs. Sympathectomy can alleviate neuropathic pain in some patients, suggesting that abnormal sympathetic-somatosensory signaling interactions might underlie some forms of neuropathic pain. The molecular mechanisms underlying sympathetic-somatosensory interactions in neuropathic pain remain obscure.