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Papers of the Week


Papers: 25 Jan 2025 - 31 Jan 2025


2025 Jan 08


Brain Sci


39851421


15


1

Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice.

Authors

Santos GX, Dos Anjos-Garcia T, Vieira ACJ, Galdino G

Abstract

Chronic postoperative pain (CPOP) is among the main consequences of surgical procedures, directly affecting the quality of life. Although many strategies have been used to treat this symptom, they are often ineffective. Thus, studies investigating CPOP-associated mechanisms may help to develop more effective treatment strategies. Therefore, the present study investigated the spinal participation of the transient potential receptor vanilloid type 1 (TRPV1) and PI3K/AKT/mTOR pathway activation during CPOP.