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Papers of the Week


Papers: 17 Jun 2023 - 23 Jun 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Neurobiology

PAIN TYPE:
Abdominal/Pelvic Pain, Psychological/Comorbidities


2023


Mol Pain


37347150


19

Spinal Cathepsin S promotes visceral hypersensitivity via FKN/CX3CR1/p38 MAPK signaling pathways.

Authors

Sun P, Lin W, Weng Y, Gong J, Huang Y, Tang Y, Lin C, Chen A, Chen Y

Abstract

Irritable bowel syndrome (IBS) is one of the typical representatives of chronic functional visceral pain that lacks effective treatment. Recently, attention has been given to the role of microglia in IBS, particularly the activation of spinal microglia and the subsequent release of Cathepsin S (Cat S), a proteolytic enzyme. However, the specific role of spinal Cat S in IBS remains to be elucidated. The purpose of this study is to investigate the mechanisms underlying the regulation of visceral hypersensitivity in IBS-like rats by Cat S.