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Papers of the Week

Papers: 16 Mar 2024 - 22 Mar 2024

2024 Mar 15

J Headache Pain




Specific cognitive and psychological alterations are more strongly linked to increased migraine disability than chronic migraine diagnosis.


Castro Zamparella T, Carpinella M, Peres M, Cuello FP, Maza P, Van Gansen M, Filipchuk M, Balaszczuk V, Maldonado C, Scarnato P, Conci Magris D, Lisicki M


The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients’ disability has recently been questioned. This prompts consideration that clinical features beyond pain may more accurately indicate the extent of underlying brain impairment than the mere frequency of headache days. Important cognitive dysfunctions and psychological impairment have been reported in burdensome cases of migraine, and the presence of these alterations has been associated with biological changes in the nervous system. This study aimed to compare migraine-related disability within a specific patient group, classified using ICHD-3 criteria or classified based on findings from a neuropsychological evaluation using machine learning. Additionally, a complementary voxel-based morphometry (VBM) comparison was conducted to explore potential neuroanatomical differences between the resulting groups.