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Papers of the Week
Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain.
Authors
Denaro S, D'Aprile S, Torrisi F, Zappalà A, Marrazzo A, Al-Khrasani M, Pasquinucci L, Vicario N, Parenti R, Parenti CAbstract
Neuropathic pain is a chronic condition characterized by aberrant signaling within the somatosensory system, affecting millions of people worldwide with limited treatment options. Herein, we aim at investigating the potential of a sigma-1 receptor (σ1R) antagonist in managing neuropathic pain.