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Papers of the Week

Papers: 10 Jun 2023 - 16 Jun 2023

Clinical, Intellectual/Developmental Disabilities

Human Studies, Molecular/Cellular, Neurobiology

2023 Jun 14

Mol Autism




Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model.


Olde Heuvel F, Ouali Alami N, Aousji O, Pogatzki-Zahn E, Zahn PK, Wilhelm H, Deshpande D, Khatamsaz E, Catanese A, Woelfle S, Schön M, Jain S, Grabrucker S, Ludolph AC, Verpelli C, Michaelis J, Boeckers TM, Roselli F


Autism Spectrum Disorders (ASD) patients experience disturbed nociception in the form of either hyposensitivity to pain or allodynia. A substantial amount of processing of somatosensory and nociceptive stimulus takes place in the dorsal spinal cord. However, many of these circuits are not very well understood in the context of nociceptive processing in ASD.