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Papers of the Week
SGK1-HDAC4-HMGB1 Signaling pathway in the spinal cord dorsal horn participates in diabetic neuropathic pain.
Authors
Zhang MB, Chen JL, Lu JH, Jia GL, Cao H, Li JAbstract
This study aimed to determine whether serum-and glucocorticoid-inducible kinase1 (SGK1) activation-dependent histone deacetylase 4 (HDAC4) phosphorylation, nucleocytoplasmic trafficking, and subsequent regulation of high-mobility group protein box 1 (HMGB1) expression are involved in type 2 diabetic neuropathic pain (DNP).