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Papers of the Week

Papers: 18 Feb 2023 - 24 Feb 2023


Animal Studies, Molecular/Cellular, Neurobiology

2023 Feb 15

Brain Res



Sestrin2 prevents neonatal incision pain and re-incision enhanced hyperalgesia in adult rats.


Shi X, Wang C, Zhao T, Gu M, Yang J, Sun N, Huang Y, Yao Y, Yu L, Yan M


Improving the methods for recognizing pain is important for infants admitted to the neonatal intensive care unit. Sestrin2 is a novel stress-inducible protein with a neuroprotective role that functions as a molecular mediator of hormesis. Nevertheless, the role of sestrin2 in the pain process is still unclear. The following study examined the role of sestrin2 on mechanical hypersensitivity after pups incision, as well as enhanced pain hyperalgesia after adulthood re-incision in rats.