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Papers of the Week


Papers: 6 May 2023 - 12 May 2023

RESEARCH TYPE:
Basic Science


Genetics, Human Studies, Molecular/Cellular

PAIN TYPE:
Abdominal/Pelvic Pain, Inflammation/Inflammatory


2023 May 11


BMC Womens Health


37170270


23


1

Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the susceptibility and severity of endometriosis in Nigerian women.

Authors

Babah OA, Ojewunmi OO, Onwuamah CK, Udenze IC, Osuntoki AA, Afolabi BB

Abstract

Endometriosis is the presence of active ectopic endometrial glands and stroma at other sites outside the uterine cavity. It is a common cause of chronic pelvic pain which is sometimes debilitating, and inflammation is one of the known triggers of endometriosis. Interleukins 6 and 16 (IL-6 and IL-16) are proinflammatory cytokines which play essential roles in inflammatory diseases. We therefore investigated the relationship between genetic polymorphisms of interleukins 6 and 16, and the development of endometriosis in Nigerian women.