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Papers of the Week


Papers: 23 Sep 2023 - 29 Sep 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Genetics, Molecular/Cellular

PAIN TYPE:
Neuropathic Pain


2023 Sep 21


Life Sci


37741322

Sensory neuron-specific long noncoding RNA in small non-peptidergic dorsal root ganglion neurons selectively impairs nerve injury-induced mechanical hypersensitivity.

Authors

Wang B, Liang Y, Bekker A, Hu H, Tao YX

Abstract

Nerve injury-induced mechanical hypersensitivity is one of major clinical symptoms in neuropathic pain patients. Understanding molecular mechanisms underlying this symptom is crucial for developing effective therapies. The present study was to investigate whether sensory neuron-specific long noncoding RNA (SS-lncRNA) predominantly expressed in small non-peptidergic dorsal root ganglion (DRG) neurons repaired nerve injury-induced mechanical hypersensitivity.