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Papers of the Week

Papers: 29 Jul 2023 - 4 Aug 2023

2023 Aug 03

N Engl J Med




Editor's Pick

Selective Inhibition of Na1.8 with VX-548 for Acute Pain.


Jones J, Correll DJ, Lechner SM, Jazic I, Miao X, Shaw D, Simard C, Osteen JD, Hare B, Beaton A, Bertoch T, Buvanendran A, Habib AS, Pizzi LJ, Pollak RA, Weiner SG, Bozic C, Negulescu P, White PF


The Na1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of Na1.8, on control of acute pain is being studied.