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Papers of the Week


Papers: 29 Jul 2023 - 4 Aug 2023


2023 Aug 03


N Engl J Med


37530822


389


5

Editor's Pick

Selective Inhibition of Na1.8 with VX-548 for Acute Pain.

Authors

Jones J, Correll DJ, Lechner SM, Jazic I, Miao X, Shaw D, Simard C, Osteen JD, Hare B, Beaton A, Bertoch T, Buvanendran A, Habib AS, Pizzi LJ, Pollak RA, Weiner SG, Bozic C, Negulescu P, White PF

Abstract

The Na1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of Na1.8, on control of acute pain is being studied.