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Papers of the Week

Papers: 16 Mar 2024 - 22 Mar 2024


J Pain Res



Scoping Review: The Role of Psychedelics in the Management of Chronic Pain.


Robinson CL, Fonseca ACG, Diejomaoh EM, D'Souza RS, Schatman ME, Orhurhu V, Emerick T


Amid a lack of effective chronic pain treatments, psychedelics have gained attention as a potential solution, although their Schedule 1 classification poses challenges. Psychedelics, such as lysergic acid diethylamide (LSD) and psilocybin, have gained popularity as alternatives and adjuncts for chronic pain treatment. Studies suggest that they may modulate pain processing through agonism primarily at the serotonin receptor, 5-HT. One of the first of its nature, we present an artificial intelligence (AI)-powered scoping review primarily focusing on evaluating psychedelics for chronic pain conditions such as cluster headache, phantom limb pain, and fibromyalgia.