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Papers of the Week

Papers: 18 May 2024 - 24 May 2024

2024 May 21

Br J Pharmacol


Schwann cell TRPA1 elicits reserpine-induced fibromyalgia pain in mice.


Brum ES, Fialho MFP, Souza Monteiro de Araújo D, Landini L, Marini M, Titiz M, Kuhn BL, Frizzo CP, Araújo PHS, Guimarães RM, Cunha TM, Silva CR, Trevisan G, Geppetti P, Nassini R, De Logu F, Oliveira SM


Fibromyalgia is a complex clinical disorder with an unknown aetiology, characterized by generalized pain and co-morbid symptoms such as anxiety and depression. An imbalance of oxidants and antioxidants is proposed to play a pivotal role in the pathogenesis of fibromyalgia symptoms. However, the precise mechanisms by which oxidative stress contributes to fibromyalgia-induced pain remain unclear. The transient receptor potential ankyrin 1 (TRPA1) channel, known as both a pain sensor and an oxidative stress sensor, has been implicated in various painful conditions.