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Papers of the Week
Schwann cell transient receptor potential ankyrin 1 (TRPA1) ortholog in zebrafish larvae mediates chemotherapy-induced peripheral neuropathy.
Authors
Bellantoni E, Marini M, Chieca M, Gabellini C, Crapanzano EL, Souza Monteiro de Araujo D, Nosi D, Roschi L, Landini L, De Siena G, Pensieri P, Mastricci A, Scuffi I, Geppetti P, Nassini R, De Logu FAbstract
The oxidant sensor transient receptor potential ankyrin 1 (TRPA1) channel expressed by Schwann cells (SCs) has recently been implicated in several models of neuropathic pain in rodents. Here we investigate whether the pro-algesic function of Schwann cell TRPA1 is not limited to mammals by exploring the role of TRPA1 in a model of chemotherapy-induced peripheral neuropathy (CIPN) in zebrafish larvae.