I am a
Home I AM A Search Login

Papers of the Week

Papers: 22 Jul 2023 - 28 Jul 2023

Basic Science

Animal Studies, Molecular/Cellular

Cancer Pain, Neuropathic Pain

2023 Jul 17

Mol Cell Neurosci


Satellite glial cell-secreted exosomes after in-vitro oxaliplatin treatment presents a pro-nociceptive effect for dorsal root ganglion neurons and induce mechanical hypersensitivity in naïve mice.


Zhao L, Liu S, Zhang X, Yang J, Mao M, Zhang S, Xu S, Feng S, Wang X


The pathophysiological mechanism underlying chemotherapy-induced neuropathic pain (CINP) remains unclear. Sensory neuronal hypersensitivity in the dorsal root ganglion (DRG) is essential for the onset and maintenance of chronic pain. Satellite glial cells (SGCs) in the DRG potentially affect the function of sensory neurons, possibly by mediating extracellular or paracrine signaling. Exosomes play an essential role in cell-cell communication. However, the role of SGC-secreted exosomes in glia-neuron communication and CINP remains unclear.