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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025 Jan 19


Neuroscience


39837364

S-ketamine alleviates morphine-induced hyperalgesia via decreasing the gut Enterobacteriaceae levels: Comparison with R-ketamine.

Authors

Liu H, Yang S, Zhang Q, Wang S, Zhang B, Xu Y, Fu X, Zhou S, Zhang P, Wang H, Di L, Xu X, Xu X, Liu C, Yang C, Wang Y, Jiang R

Abstract

Opioid-induced hyperalgesia (OIH) is a serious complication during the pain treatment. Ketamine has been commonly reported to treat OIH, but the mechanisms remain unclear. Gut microbiota is recently recognized as one of the important mechanisms underlying the occurrence and treatment of OIH. However, whether ketamine enantiomers could alleviate OIH through gut microbiota that still needs to be clarified.