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Papers of the Week
Relief of pain in mice by an antibody with high affinity for cell adhesion molecule 1 on nerves.
Authors
Takeuchi F, Hagiyama M, Yoneshige A, Wada A, Inoue T, Hosokawa Y, Ito AAbstract
Cell adhesion molecule 1 (CADM1) is a member of the immunoglobulin superfamily and is abundantly expressed on nerve fibers. Recently, the anti-CADM1 ectodomain antibody 3E1 has proven useful as a drug delivery vector for CADM1-expressing cells in vitro. When injected subcutaneously into mice, whether 3E1 accumulates on nerve fibers and serves as an analgesic was examined.