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Papers of the Week

Papers: 28 Oct 2023 - 3 Nov 2023

2023 Oct 18



Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis.


Obeidat AM, Kim SY, Burt KG, Hu B, Li J, Ishihara S, Xiao R, Miller RE, Little C, Malfait AM, Scanzello CR


Synovial pathology has been linked to osteoarthritis (OA) pain in patients. Microscopic grading systems for synovial changes in human OA have been described, but a standardized approach for murine models of OA is needed. We sought to develop a reproducible approach and set of minimum recommendations for synovial histopathology in mouse models of OA.