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Papers of the Week
Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis.
Authors
Obeidat AM, Kim SY, Burt KG, Hu B, Li J, Ishihara S, Xiao R, Miller RE, Little C, Malfait AM, Scanzello CRAbstract
Synovial pathology has been linked to osteoarthritis (OA) pain in patients. Microscopic grading systems for synovial changes in human OA have been described, but a standardized approach for murine models of OA is needed. We sought to develop a reproducible approach and set of minimum recommendations for synovial histopathology in mouse models of OA.