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Papers of the Week

Papers: 16 Mar 2024 - 22 Mar 2024

2024 Mar 19

Cell Rep Med




Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.


Zhang J, Zhao W, Zhou Y, Xi S, Xu X, Du X, Zheng X, Hu W, Sun R, Tian Z, Fu B, Wei H


Endometriosis, affecting 6%-10% of women, often leads to pain and infertility and its underlying inflammatory mechanisms are poorly understood. We established endometriosis models in wild-type and IL16KO mice, revealing the driver function of IL-16 in initiating endometriosis-related inflammation. Using an in vitro system, we confirmed iron overload-induced GSDME-mediated pyroptosis as a key trigger for IL-16 activation and release. In addition, our research led to the development of Z30702029, a compound inhibiting GSDME-NTD-mediated pyroptosis, which shows promise as a therapeutic intervention for endometriosis. Importantly, our findings extend beyond endometriosis, highlighting GSDME-mediated pyroptosis as a broader pathway for IL-16 release and offering insights into potential treatments for various inflammatory conditions.