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Papers of the Week

Papers: 27 May 2023 - 2 Jun 2023

Basic Science

Animal Studies, Molecular/Cellular, Neurobiology, Neuromodulation


J Pain Res



Pulsed Radiofrequency Decreases pERK and Affects Intracellular Ca Influx, Cytosolic ATP Level, and Mitochondrial Membrane Potential in the Sensitized Dorsal Root Ganglion Neuron Induced by N-Methyl D-Aspartate.


Laksono RM, Kalim H, Rohman MS, Widodo N, Ahmad MR, Halim W


The molecular mechanism of pulsed radiofrequency (PRF) in chronic pain management is not fully understood. Chronic pain involves the activation of specific N-Methyl D-Aspartate receptors (NMDAR) to induce central sensitization. This study aims to determine the effect of PRF on central sensitization biomarker phosphorylated extracellular signal-regulated kinase (pERK), Ca influx, cytosolic ATP level, and mitochondrial membrane potential (Δψm) of the sensitized dorsal root ganglion (DRG) neuron following NMDAR activation.