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Papers of the Week
Psychological stress-induced local immune response to food antigens increases pain signaling across the gut in mice.
Authors
Aguilera-Lizarraga J, Lopez-Lopez C, Jaramillo-Polanco J, Florens MV, Yu Y, Tsang QK, Chakraborty A, De Gand S, Pia F, Quan R, Cuende-Estévez M, Van Remoortel S, Strid J, Lomax AE, Berin MC, Craig AW, Kaufmann E, Ormiston ML, Vanner SJ, Hussein H, Boeckxstaens GE, Reed DEAbstract
We recently showed that a bacterial infection can break oral tolerance to food and lead to IgE-dependent mast cell activation and food-induced abdominal pain, which could constitute an important pathogenic mechanism in post-infectious irritable bowel syndrome (IBS). Here, we investigated whether similar immune mechanisms in response to psychological stress lead to food-evoked pain signaling, and thus potentially explain the pathophysiology in a larger group of patients with IBS.