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Papers of the Week


Papers: 11 Jan 2025 - 17 Jan 2025


2025 Jan 16


Clin Exp Immunol


39817476

Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis.

Authors

Smith KJ, Lim Z, Vermeren S, Miron VE, Dimeloe S, Davidson DJ, Williams A, Gwyer Findlay E

Abstract

Multiple Sclerosis (MS) is a complex auto-inflammatory disease affecting the brain and spinal cord, which results in axonal de-myelination and symptoms including fatigue, pain, and difficulties with vision and mobility. The involvement of the immune system in the pathology of MS is well established, particularly the adaptive T cell response, and there has been a particular focus on the IL-17-producing subset of Th17 cells and their role in driving disease. However, the importance of innate immune cells has not been so well characterised.