I am a
Home I AM A Search Login

Papers of the Week

Papers: 1 Jul 2023 - 7 Jul 2023

Basic Science

Animal Studies, Genetics, Molecular/Cellular, Neurobiology

Cancer Pain, Neuropathic Pain

2023 Jun 30

Anesth Analg


Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion.


Yeh CM, Lai CY, Peng HY, Lin TB, Chou D, Wang HH, Yang PS, Cheng JK, Peng YC, Hsieh MC


Paclitaxel (PTX), which is a first-line chemotherapy drug used to treat various types of cancers, exhibits peripheral neuropathy as a common side effect that is difficult to treat. Protein arginine methyltransferase 5 (PRMT 5) is a key regulator of the chemotherapy response, as chemotherapy drugs induce PRMT5 expression. However, little is known about the PRMT5-mediated epigenetic mechanisms involved in PTX-induced neuropathic allodynia.