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Pregnenolone sulfate potentiates tetrodotoxin-resistant Na channels to increase the excitability of dural afferent neurons in rats.
Authors
Jang IS, Nakamura MAbstract
Although peripheral administration of pregnenolone sulfate (PS) has been reported to produce pronociceptive effects, the mechanisms by which PS modulates the excitability of nociceptive neurons are poorly understood. Here, we report on the excitatory role of PS in peripheral nociceptive neurons, focusing on its effects on tetrodotoxin-resistant (TTX-R) Na channels.