I am a
Home I AM A Search Login

Papers of the Week

Papers: 4 Nov 2023 - 10 Nov 2023

2023 Nov 02

Eur J Pharmacol


Pregabalin inhibits purinergic P2Y receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain.


Song S, Wang Q, Qu Y, Gao W, Li D, Xu X, Yue S


Transient receptor potential vanilloid 4 (TRPV4)-mediated astrocyte activation is critical to neuropathic pain. Pregabalin, a widely used drug to treat chronic pain, is reported to lower the intracellular calcium level. However, the molecular mechanism by which pregabalin decreases the intracellular calcium level remains unknown. Purinergic P2Y receptor-a member of the G protein-coupled receptor (GPCR) family-regulates calcium-related signal transduction in astrocyte activation. We investigated whether P2Y receptor is involved in the pharmacological effects of pregabalin on neuropathic pain.