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Papers of the Week
Predictive and concurrent validity of pain sensitivity phenotype, neuropeptidomics and neuroepigenetics in the MI-RAT osteoarthritic surgical model in rats.
Authors
Otis C, Cristofanilli KA, Frezier M, Delsart A, Martel-Pelletier J, Pelletier JP, Beaudry F, Lussier B, Boyer A, Troncy EAbstract
Micro-RNAs could provide great insights about the neuropathological mechanisms associated with osteoarthritis (OA) pain processing. Using the validated ontreal nduction of at rthritis esting (MI-RAT) model, this study aimed to characterize neuroepigenetic markers susceptible to correlate with innovative pain functional phenotype and targeted neuropeptide alterations.