Browse by Audience
Skip to content
Papers of the Week
Prediction and validation of anoikis-related genes in neuropathic pain using machine learning.
Authors
He Y, Wei Y, Wang Y, Ling C, Qi X, Geng S, Meng Y, Deng H, Zhang Q, Qin X, Chen GAbstract
Neuropathic pain (NP) can be induced by a variety of clinical conditions, such as spinal cord injury, lumbar disc herniation (LDH), lumbar spinal stenosis, diabetes, herpes zoster, and spinal cord tumors, and inflammatory stimuli. The pathogenesis of NP is extremely complex. Specifically, in LDH, the herniated nucleus pulposus exerts mechanical pressure on nerve roots, triggering local inflammation and consequent NP. Anoikis, a special form of programmed cell death, is closely related to the progression of NP. In this study, we sought to clarify the molecular characteristics of anoikis-related genes in NP, providing novel insights for the diagnosis and treatment of NP.