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Papers of the Week


Papers: 16 Sep 2023 - 22 Sep 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Pharmacology/Drug Development

PAIN TYPE:
Psychological/Comorbidities


2023


Pain Rep


37731750


8


2

Preclinical study in a postoperative pain model to investigate the action of ketamine, lidocaine, and ascorbic acid in reversing fentanyl-induced, non-glutamate-dependent hyperalgesia.

Authors

Delgado MA, Ferreira LA, Gomes BJDS, Leite IKO, Gomez MV, Castro-Junior C

Abstract

Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon in which exposure to opioids can increase sensitivity to painful stimuli. Currently, several drugs have been used in an attempt to prevent OIH. We design this study to address the effect of preemptive treatment with ketamine, lidocaine, and ascorbic acid in a rat preclinical model of perioperative opioid-induced hyperalgesia.