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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025 Jan 20


BMC Gastroenterol


39833676


25


1

PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress.

Authors

Li M, Zhuo X, Liu Y, You J, Lin J

Abstract

Visceral pain sensitization and emotional reactions due to irritable bowel syndrome (IBS) occur frequently in the general population. Oxidative stress plays a crucial role in the pathogenesis of IBS. Previous studies have demonstrated that activation of peroxisome proliferator-activated receptor gamma (PPARγ) has analgesic effects. Therefore, we aimed to determine whether PPARγ activation ameliorates oxidative stress and affects thus nociceptive sensitization and emotional responses in IBS.