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Papers of the Week


Papers: 11 Jan 2025 - 17 Jan 2025


2025 Mar


Osteoarthr Cartil Open


39811690


7


1

Postnatal deletion of Phlpp1 in chondrocytes delays post-traumatic osteoarthritis in male mice.

Authors

Weaver SR, Arnold KM, Peralta-Herrera E, Oviedo M, Zars EL, Bradley EW, Westendorf JJ

Abstract

Osteoarthritis is a chronic, debilitating disease that causes long-term pain and immobility. Germline deletion of Phlpp1 or administration of small molecules that inhibit Phlpp1 prevents post-traumatic osteoarthritis (PTOA) in mice. However, the chondrocyte-intrinsic role of Phlpp1 in PTOA progression is unknown. The objective of this study was to determine how postnatal, chondrocyte-directed deletion of Phlpp1 affects PTOA progression in the presence or absence of Phlpp inhibitors.