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Papers: 15 Jun 2024 - 21 Jun 2024

2024 Jun 18

Ann Clin Transl Neurol


Pituitary cyclase-activating polypeptide targeted treatments for the treatment of primary headache disorders.


Karsan N, Edvinsson L, Vecsei L, Goadsby PJ


Migraine is a complex and disabling neurological disorder. Recent years have witnessed the development and emergence of novel treatments for the condition, namely those targeting calcitonin gene-related peptide (CGRP). However, there remains a substantial need for further treatments for those unresponsive to current therapies. Targeting pituitary adenylate cyclase-activating polypeptide (PACAP) as a possible therapeutic strategy in the primary headache disorders has gained interest over recent years.