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Papers of the Week


Papers: 18 Feb 2023 - 24 Feb 2023

RESEARCH TYPE:
Commentary/Perspective

PAIN TYPE:
Abdominal/Pelvic Pain


2023 Feb 15


Neuron


36796326


111


4

Piezo2 mediates visceral mechanosensation: A new therapeutic target for gut pain?

Authors

Xu J, McGinnis A, Ji RR

Abstract

Mechanical distension/stretch in the colon provokes visceral hypersensitivity and pain. In this issue of Neuron, Xie et al. report that mechanosensitive Piezo2 channels, expressed by TRPV1-lineage nociceptors, are involved in visceral mechanical nociception and hypersensitivity.