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Papers of the Week


Papers: 15 Apr 2023 - 21 Apr 2023

RESEARCH TYPE:
Translational


Human Studies, Molecular/Cellular, Neurobiology

PAIN TYPE:
Arthritis, Inflammation/Inflammatory


2023 Apr 17


J Transl Med


37069596


21


1

Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies.

Authors

Fu W, Ge M, Li J

Abstract

Acute gouty arthritis is inflammatory joint arthritis. Gouty arthritis (GA) involves multiple pathological processes. Deposition of joints by monosodium urate (MSU) crystals has been shown to play a critical role in the injury process. Due to the different effects of MSU stimulation on the joints, the exact changes in the synovial fluid are unknown. We want to explore the changes in proteins and metabolites in the joints of gouty arthritis. Regulating various functional substances in the joint can reduce inflammation and pain symptoms.