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Papers of the Week
Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders.
Authors
Macphee CH, Dong X, Peng Q, Paone DV, Skov PS, Baumann K, Roethke T, Goldspink DA, Pearson SK, Wu ZAbstract
Because MRGPRX2 is now recognized as the mast cell receptor for basic secretagogues, there is currently a tremendous interest in whether MRGRPX2 could play an important role in various pruritic dermatoses such as chronic spontaneous urticaria. Therefore, we sought to identify new potent and selective antagonists to pharmacologically characterize the biological role of MRGPRX2.