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Papers of the Week


Papers: 22 Mar 2025 - 28 Mar 2025


2025 Mar 25


Eur J Pharmacol


40147577

Pharmacokinetics of Oxycodone in Rats: Influence of Micronized Magnesium Lactate on Oxycodone Bioavailability.

Authors

Hijano DO, Flis S, Ofiara K, Strus B, Szterk A

Abstract

This article presents studies on the pharmacokinetics of oxycodone hydrochloride and the influence of micronized magnesium lactate on its bioavailability and pharmacokinetic parameters. Two methods, HPLC-DAD, and HPLC-MS/MS, were developed and validated to investigate the content of oxycodone hydrochloride in the developed medicinal products and, oxymorphone in blood serum using an isotopic dilution method. The aim was to develop a novel pharmaceutical formulation combining oxycodone hydrochloride with Mg , which could increase the efficacy of analgesia while reducing the opioid dose. Experiments were conducted on Wistar rats, analyzing the changes in plasma concentrations of oxycodone hydrochloride and its metabolite oxymorphone after intragastric administration of two formulations: one containing oxycodone hydrochloride alone and the other with the addition of micronized magnesium lactate. The results indicate that the presence of Mg decrease the bioavailability of oxycodone, which is related to chemical reactions between the formulation components. This phenomenon has been overlooked by other researchers determining the interaction of Mg with opioids in enhancing the antinociceptive effect of opioids.