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Papers of the Week


Papers: 28 Oct 2023 - 3 Nov 2023


2023 Nov 02


Clin Drug Investig


37917246

Pharmacokinetics and Safety of Eptinezumab in Healthy Chinese Participants: A Randomized Clinical Trial.

Authors

Li XN, Xu HR, Cui E, Petersen KB, Ryding J, Ettrup A, Østergaard JB, Larsen F

Abstract

Most evidence suggests that the pharmacokinetics of monoclonal antibodies (mAbs) are not meaningfully altered by patient characteristics, including racial/ethnic differences. Nevertheless, the pharmacokinetic profile of eptinezumab has not been evaluated in a Chinese population. This study was designed to confirm the hypothesis that the pharmacokinetic profile of the anti-calcitonin gene-related peptide mAb, eptinezumab, is similar in healthy Chinese individuals to that of healthy non-Asian individuals and non-Asian patients with migraine.