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Papers of the Week
Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration.
Authors
Xin L, Zhu H, Niu S, Han X, Pang H, Li J, Hu Y, Wang X, Li L, Fang YAbstract
The aim of this study was to establish a pharmacodynamic model of tapentadol analgesia under dose titration conditions, to quantitatively analyze the time-effect relationship of the drug, and to identify relevant influencing factors. This model is intended to provide a pharmacodynamic reference for designing rational tapentadol dose titration schemes in clinical research.