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Papers of the Week

Papers: 29 Jun 2024 - 5 Jul 2024

2024 Jul 04

J Headache Pain




Persistent effectiveness of CGRP antibody therapy in migraine and comorbid medication overuse or medication overuse headache – a retrospective real-world analysis.


Scheffler A, Basten J, Menzel L, Binz D, Becker WA, Breunung V, Schenk H, Kleinschnitz C, Nsaka M, Lindner D, Holle D


Management of patients with migraine who have concomitant medication overuse (MO) or medication overuse headache (MOH) is a major problem in clinical practice. Detoxification of acute analgesics before or during initiation of prophylactic therapy has long been recommended although this concept has recently been questioned. Additionally, relapse after detoxification is a common problem. This real-world study analyses the initial and sustained effectiveness of prophylactic migraine therapy with CGRP (receptor) antibodies without prior detoxification in patients with comorbid MO or MOH for up to one year.