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Papers of the Week

Papers: 29 Jul 2023 - 4 Aug 2023

2023 Jul 28

Br J Pharmacol


Pamoic Acid-Induced Peripheral GPR35 Activation Improves Pruritus and Dermatitis.


Kim C, Kim Y, Lim JY, Kim M, Zheng H, Kim M, Hwang SW


Pruritic dermatitis is a disease with a considerable unmet need for treatment and appears to present with not only epidermal but also peripheral neuronal complications. Here we propose a novel pharmacologic modulation targeting both peripheral dorsal root ganglion (DRG) sensory neurons and skin keratinocytes. GPR35 is an orphan G-protein-coupled receptor expressed in DRG neurons and has been predicted to downregulate neuronal excitability when activated. Modulator information is currently increasing for GPR35 and pamoic acid (PA), a salt-forming agent for drugs, has been shown to be an activator solely specific for GPR35. Here we investigated its effect on dermatitic pathology.