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Papers of the Week

Papers: 8 Jun 2024 - 14 Jun 2024

2024 Jun 11

J Headache Pain




PACAP-38 and sex hormones in women with migraine: exploratory analysis of a cross-sectional, matched cohort study.


Storch E, Overeem LH, Terhart M, Fitzek MP, Lange KS, Reuter U, Raffaelli B


Endogeneous and exogeneous sex hormones can impact the frequency and severity of migraine attacks, but the underlying mechanisms are poorly understood. In this study, we investigate the relationship between female sex hormones and Pituitary Adenylate Cyclase-Activating Polypeptide-38 (PACAP-38) concentrations in plasma of women with migraine and healthy controls, aiming to elucidate potential hormonal influences on PACAP dynamics and their relevance to migraine pathophysiology.