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Papers of the Week

Papers: 19 Aug 2023 - 25 Aug 2023

Basic Science

Human Studies, Molecular/Cellular, Neurobiology

Cancer Pain, Neuropathic Pain, Psychological/Comorbidities

2023 Aug 21

Scand J Pain


Oxaliplatin causes increased offset analgesia during chemotherapy – a feasibility study.


Mørch CD, Szpejewska JE, Poulsen LØ, Yilmaz MN, Falkmer UG, Arendt-Nielsen L


Offset analgesia (OA) is the phenomenon where the perceived pain intensity to heat stimulation disproportionally decreases after a slight decrease in stimulation temperature. The neural mechanisms of OA are not fully understood, but it appears that both peripheral and central temporal filtering properties are involved. Chemotherapy with oxaliplatin often causes acute peripheral sensory neuropathy, and manifests primarily as a cold induced allodynia. The aim of this exploratory patient study was to investigate if OA was affected by the neurotoxic effects of adjuvant oxaliplatin treatment.