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Papers of the Week


Papers: 13 May 2023 - 19 May 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Pharmacology/Drug Development

PAIN TYPE:
Inflammation/Inflammatory, Neuropathic Pain


2023 May 12


Eur J Pain


37172202

NS5806 reduces carrageenan-evoked inflammation by suppressing extracellular signal-regulated kinase activation in primary sensory neurons and immune cells.

Authors

Yang PY, Tsaur ML

Abstract

The compound NS5806 attenuates neuropathic pain via inhibiting extracellular signal-regulated kinase (ERK) activation in neuronal somata located at the dorsal root ganglion (DRG) and superficial spinal dorsal horn. NS5806 also reduces the expansion of DRG macrophages and spinal microglia several days after peripheral nerve injury, implying an anti-inflammatory effect.