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Papers of the Week
Novel endomorphin analogs CEMR-1 and CEMR-2 produce potent and long-lasting antinociception with a favorable side effect profile at the spinal level.
Authors
Zhang YZ, Wang SY, Guo XC, Liu XH, Wang XF, Wang MM, Qiu TT, Han FT, Zhang Y, Wang CLAbstract
Endomorphins (EMs) have shown great promise as pharmaceutics for the treatment of pain. We have previously confirmed that novel EM analogs CEMR-1 and CEMR-2 behaved as potent μ-opioid receptor agonists and displayed potent antinociceptive activities at the supraspinal and peripheral levels. Herein, the present study was undertaken to evaluate the antinociceptive properties of CEMR-1 and CEMR-2 following intrathecal (i.t.) administration. Furthermore, their antinociceptive tolerance and opioid-like side effects were also determined.