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Papers of the Week

1975 Dec 18




Classic Paper

Identification of two related pentapeptides from the brain with potent opiate agonist activity.


Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR
Nature. 1975 Dec 18; 258(5536):577-80.
PMID: 1207728.


Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.